Abstract: Researchers discovered that Parkinson’s illness (PD) sufferers with sympathetic denervation in main salivary glands and the center exhibit extra extreme non-motor signs as they age.
This analysis highlights the significance of age in PD development and will improve the understanding of the illness’s pathophysiology.
Key Information:
- Non-Motor Signs: Older PD sufferers with sympathetic denervation present extreme olfactory dysfunction, REM sleep conduct dysfunction, and autonomic nervous system dysfunction.
- MIBG Scintigraphy: The examine used a quantitative technique to research MIBG uptake, exhibiting a correlation between denervation and symptom severity.
- Age Issue: Age considerably impacts the development of non-motor signs in PD, unbiased of cognitive perform and sickness period.
Supply: Toho College
Dr. Junya Ebina and Professor Osamu Kano from the Division of Neurology, Toho College College of Drugs, together with Professor Sunao Mizumura from the Division of Radiology, have reported that sufferers with Parkinson’s illness (PD) exhibiting sympathetic denervation within the main salivary glands and the center are likely to have extra superior non-motor signs as they age, suggesting that age performs an vital function in illness development.
This analysis final result may probably contribute to a greater understanding of the pathophysiological development of PD.
This examine was made out there on-line on February 12, 2024 and was revealed in Article 122932, Quantity 458 of the Journal of the Neurological Sciences, on 15 March 2024.
Key Factors:
- PD sufferers with sympathetic denervation within the main salivary glands and coronary heart , as indicated by MIBG scintigraphy (Word 1), are older and have extra extreme non-motor signs, akin to olfactory dysfunction, REM sleep conduct dysfunction, and autonomic nervous system dysfunction in response to questionnaire scores, in comparison with teams with single sympathetic denervation or non-sympathetic denervation (Desk and Determine). Nevertheless, cognitive perform, period of sickness, and MDS-UPDRS motor symptom scores had been comparable between the teams.
- On this examine, a quantitative semi-automatic technique developed by the analysis group final 12 months was used to research MIBG uptake within the main salivary glands and coronary heart. This comparative examine of medical signs specializing in peripheral organs in sufferers with PD, as highlighted in Ebina J, et al. J Neurol 2023, could present a brand new perspective on illness development.
- This examine could contribute to understanding the pathophysiological development of PD, resulting in a extra correct staging of PD and enabling tailor-made medical care in response to particular person affected person circumstances. The analysis group can be inspecting the utility of novel adjunct diagnostic strategies.
Presentation Overview:
PD is a progressive neurodegenerative dysfunction characterised by irregular aggregates of α-synuclein often known as Lewy our bodies. Lewy our bodies will not be solely discovered within the central nervous system but in addition in peripheral organs.
In PD, cardiac sympathetic denervation detected by 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy is related to the presence of Lewy our bodies. Conversely, though Lewy our bodies are continuously discovered within the digestive tract, together with within the main salivary glands, the method of pathophysiological development in peripheral organs is unclear.
A analysis group beforehand reported sympathetic denervation within the submandibular and parotid glands of sufferers with PD. Subsequently, on this examine, they hypothesized and verified whether or not sufferers with PD and sympathetic nerve dysfunction within the coronary heart and main salivary glands have extra superior medical signs.
Sufferers with PD with sympathetic denervation in each main salivary glands and coronary heart areas (dual-SD group) had been discovered to be older, have extra extreme olfactory dysfunction, and a better chance of getting REM sleep conduct dysfunction and extreme autonomic nerve dysfunction in comparison with the single-SD group or non-SD group.
Nevertheless, the period of sickness and cognitive perform had been comparable among the many teams. Logistic regression evaluation with age, intercourse, and period of sickness as variables confirmed that age was an vital issue affecting medical analysis objects within the development of the illness.
In conclusion, sufferers with PD and decreased MIBG uptake in each the foremost salivary glands and coronary heart areas exhibited a development of signs centered round non-motor signs, suggesting that autonomic nerve dysfunction could progress independently of nigrostriatal dopaminergic degeneration.
Moreover, the potential contribution of age to the pathophysiological development of PD was urged. This examine could support in understanding the pathophysiological development of PD and could also be used for future staging of particular person sufferers.
About this Parkinson’s illness analysis information
Writer: akira muto
Supply: Toho College
Contact: Akira Muto – Toho College
Picture: The picture is credited to Neuroscience Information
Authentic Analysis: Open entry.
“Medical traits of sufferers with Parkinson’s illness with diminished 123I-metaiodobenzylguanidine uptake within the main salivary glands and coronary heart” by Junya Ebina et al. Journal of the Neurological Sciences
Summary
Medical traits of sufferers with Parkinson’s illness with diminished 123I-metaiodobenzylguanidine uptake within the main salivary glands and coronary heart
Highlights
- MIBG uptake within the main salivary glands is diminished in Parkinson’s illness.
- Parkinson’s illness with twin diminished MIBG uptake exhibits superior non-motor signs.
- Autonomic dysfunction would possibly progress independently from dopaminergic degeneration.
- Growing older is a vital consider Parkinson’s illness.
Summary
Background
Parkinson’s illness (PD) exhibits cardiac sympathetic denervation (SD) in 123I-metaiodobezylguanidine (MIBG) scintigraphy. Not too long ago, SD within the main salivary glands (MSG-SD) was launched as a doable radiological characteristic of PD.
goal
To determine the medical traits of sufferers with PD with diminished MSG and cardiac MIBG uptake (dual-SD) in contrast with these with diminished MSG or cardiac MIBG uptake solely (single-SD).
Strategies
We recruited 90 sufferers with PD and 30 controls and evaluated their non-motor (eg, hyposmia, autonomic dysfunction) and motor (eg, Motion Dysfunction Society-Unified Parkinson’s Illness Ranking Scale) options. We additionally assessed MIBG uptake within the MSG and coronary heart utilizing a quantitative semi-automatic technique, and in contrast MIBG uptakes between PD and controls. We set cut-off values for optimum sensitivity and specificity, and in contrast the medical traits of sufferers with PD between dual- and single-SD teams.
Outcomes
MSG and cardiac MIBG uptakes had been considerably diminished in PD. Sixty-one sufferers had dual-SD, 25 had single-SD, and 4 had non-SD. In sufferers with PD with regular cardiac SD, 76.5% (13/17) of whom confirmed abnormalities solely in MSG-SD. When medical traits had been in contrast between the dual-SD and single−/non-SD teams, sufferers within the dual-SD group had been older and had extra extreme hyposmia and autonomic dysfunction, besides motor options. A number of logistic regression evaluation recognized age as an vital confounder.
Conclusions
Sufferers with PD with dual-SD have extra extreme non-motor options than different sufferers. Autonomic dysfunction would possibly progress independently from dopaminergic degeneration. Moreover, our findings point out that growing old is a vital consider PD development.
